Intake of food pellets containing pre-germinated brown rice alleviates cognitive deficits caused by β-amyloid peptide25-35 in mice: Implication of lipid peroxidation

Rice is an important energy source for people worldwide. The rice grain consists of an endosperm, a bran layer and a germ. However, polished rice lacks the bran and germ, which are abundant in dietary fiber, vitamins and minerals. Polished rice is one of the main staples in Asian countries. On the other hand, pre-germinated brown rice (PGBR) is rapidly becoming popular as a health food in Japan. PGBR is brown rice soaked in water to induce slight germination and is known to contain an abundance of nutrients, including 13 times the amount of g-oryzanol, a potent antioxidant, present in polished rice. In a recent study, we revealed that ferulic acid (4-hydroxy-3-methoxycinnamic acid; FA), a main and active metabolite of g-oryzanol attenuated oxidative stress-induced memory impairment in mice [1].